Distribution and Transmission of Enterobacteriaceae Clinical Isolates Co-resistant to Colistin and Carbapenem in Gangwon Province, South Korea

The emergence of Enterobacteriaceae strains resistant to both colistin and carbapenem, which harbor the mobile resistance (mcr) gene, has become a significant clinical public health concern. aim this study was identify with co-resistance carbapenem gain further understanding antimicrobial characteristics these in South Korea. Bacterial identification performed using MALDI Biotyper Vitek2 compact, antibiotic susceptibility tested broth microdilution agar disk diffusion, genes were detected polymerase chain reaction. Pulsed-field gel electrophoresis (PFGE) used compare colistin. In study, total 66 (9.9%) isolates obtained, all exhibited concurrent Among isolates, seven carried mcr-8 (n=1), mcr-9 (n=5), mcr-10 (n=1) genes, respectively. Notably, five an identical pulsotype Enterobacter cloacae complex obtained from patients at same hospital, while 11 Klebsiella pneumoniae or different hospitals Gangwon Province, Fortunately, none that transmitted mcr gene. To best our knowledge, is confirmation transmission circulation carbapenem- colistin-resistant nosocomial and/or local community setting These results underscore importance implementing effective infection control measures continuously monitoring bacteria.